Select a region with data to zoom. Data compilation copyright Caffeic Acid and chlorogenic acid from coffee beans both reduced DNA methylation in vitro in two lines of human cancer cells. 3-O-caffeoylshikimic acid (dactylifric acid) and its isomers, are enzymic browning substrates found in dates (Phoenix dactylifera fruits). CAPE significantly reduced the number of papillomas. Caffeic acid phenethyl ester (CAPE) is an active component of propolis from honeybee hives. Both are part of the carbocyclic carboxylic acid group.[2]. Isomers with the same molecular formula and in the hydroxycinammic acids family are: InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+, InChI=1/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+, Except where otherwise noted, data are given for materials in their, International Agency for Research on Cancer, "Functional role of anthocyanins in the leaves of, "The Liquid Chromatographic Determination of Chlorogenic and Caffeic Acids in Xu Duan (Dipsacus asperoides) Raw Herb", "Protein glycation inhibitors from the fruiting body of, "Showing all foods in which the polyphenol Caffeic acid is found - Phenol-Explorer", "Determination of Flavonoids, Phenolic Acids, and Xanthines inMateTea (Ilex paraguariensisSt.-Hil. © 1997-2020 LUMITOS AG, All rights reserved, https://www.chemeurope.com/en/encyclopedia/Caffeic_acid.html, Your browser is not current. Caffeic acid structure (Source – PubChem) What is Caffeic Acid? The HardyDisk™ Caffeic Acid Disks are a modification of this rapid method and provide for the presumptive identification of Cryptococcus neoformans within four hours. errors or omissions in the Database. [28] The developing chemistry is similar to that of catechol or pyrogallol. [24], Caffeic acid is susceptible to autoxidation.With transition metals,it forms transition metal-carboxylate complexes,but not salts. [19] Oral administration of high doses of caffeic acid in rats has caused stomach papillomas. Find out more about the company LUMITOS and our team. It is found at a high level in some herbs, especially thyme, sage and spearmint (at about 20 mg per 100 g), at high levels in spices, especially Ceylon cinnamon and star anise (at about 22 mg per 100 g), found at fairly high level in sunflower seeds (8 mg per 100 g), and at modest levels in red wine (1.88 mg per 100 ml) and in apple sauce, apricots and prunes (at about 1 mg per 100 g). In the same study, only high doses of combined antioxidants, including caffeic acid, showed a significant decrease in growth of colon tumors in those same rats. [4] It can also be found in the freshwater fern Salvinia molesta[5] and in the mushroom Phellinus linteus. It exists in cis and trans forms; the latter is the more common. [18], Studies of the carcinogenicity of caffeic acid have mixed results. intended to imply recommendation or endorsement by the National Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director. the library and This opens the door to use as a natural fungicide by supplementing trees with antioxidants. To use all functions of this page, please activate cookies in your browser. Caffeate O-methyltransferase is an enzyme responsible for the transformation of caffeic acid into ferulic acid. [12] It is known to have antimitogenic, anticarcinogenic, anti-inflammatory, and immunomodulatory properties. Categories: Carboxylic acids | Aromatic compounds. Stars This opens the door to using natural anti-fungicide methods by supplementing trees with antioxidants. [7] It is also quite high in the South American herb yerba mate (150 mg per 100 g based on thin layer chromatography densiometry [8] and HPLC [9]).
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