Grapefruit can increase the potency of many drugs (including simvastatin) from the normal dose up to 4 to 5 times of the dosage. Minimal-work, done-in-a-flash recipes can actually feed you well. Vary your workouts to get the best results: mix endurance training (running, swimming, walking) with power training (weight lifting) and yoga for an all-around workout that will keep you active longer. The interaction is caused by an organic compound in grapefruit known as furanocoumarin. Furanocoumarins are found in other fruits and vegetables (such as celery, parsnips, and pomegranates), but are especially high in grapefruit and grapefruit juice. You only need to activate your account once. Grapefruit also interacts with drugs used to treat nausea and urinary tract infections, anti-rejection drugs, medications to treat cancer, and many drugs that affect the central nervous system, including anti-anxiety drugs. Grapefruit juice inhibits this enzyme so the liver produces less of it, and this affects the action of those drugs – they will be less effective. Last medically reviewed on April 29, 2019, Vitamin F is not a vitamin in the traditional sense, but a term for two important fats. © 2010 - 2020 Harvard University. The effect of … Milder side effects include muscle and joint pain.
Other statin drugs remain largely unaffected by the consumption of grapefruit. Cardiovascular health among youths still has…, In a pair of articles published today in the New England Journal of Medicine, researchers tout the potential of bempedoic acid as a powerful new tool…, As far as natural alternatives to chemical ingredients go, capric acid and caprylic triglyceride is one of the cleanest ingredients that you can find…. If I have a grapefruit or glass of grapefruit juice, is there a safe amount of time I should wait before taking my medication or vice versa? The no-drug approach to erectile dysfunction, A silent condition may be taking a toll on your health. Some cholesterol medications called statins are affected by grapefruit. However, check with your doctor if you experience ill effects, since it’s unclear how common these interactions are. These foods can also affect how your body metabolizes the medication. For example, you might need to stop taking lovastatin, atorvastatin, or simvastatin, but you might be able to take fluvastatin, pitavastatin, pravastatin, or rosuvastatin to lower your cholesterol. If you truly love grapefruit and can't do without it, ask your doctor about switching to another statin or lowering your dose. 2016;129(1):26-9. doi:10.1016/j.amjmed.2015.07.036, Cleveland Clinic. © 2005-2020 Healthline Media a Red Ventures Company. They prevent your body from making more cholesterol. Please note the date of last review or update on all articles. A slower breakdown of a drug means you’ll have more of that drug in your bloodstream. Err on the side of caution and restrict drinking and eating grapefruit if you take one of these statins, at least until you discuss the risks with your doctor. Although grapefruit interacts with over 85 medications, not all of the interactions cause serious side effects. The FDA reports that the risk of muscle breakdown and liver damage can lead to kidney failure. Statins are a class of drugs that lower LDL, or “bad,” cholesterol levels in the body by preventing production in the liver, where the majority of the…, Many medications can be used to treat high blood pressure. Statins are prescription drugs used to lower cholesterol. There are other types of drugs that may be affected by grapefruit, too. Being overweight or having diabetes might require statin use as well. As it turns out, this claim is true. How this translates to the "safe" consumption of grapefruit remains unclear. Enter search terms and tap the Search button. Neurological side effects include confusion and memory loss, according to the Mayo Clinic. At present, no one really knows where the "safe" line is. Q: I've heard that people shouldn't drink grapefruit juice if they're taking a statin.
The main agents responsible for the grapefruit juice effect on statins are bergamottin in fresh grapefruit and its derivative, 6′,7′-dihydroxybergamottin (DHB) in juice concentrate, which are furanocoumarins.
Written by the Healthline Editorial Team, How grapefruit interacts with certain statins. Why Grapefruit and Statin Drugs Do Not Mix, Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved. Grapefruit juice and some drugs don't mix. Muscle strength is linked to just about every physiological system, so strength training is critical to well-being. Statin drugs, also known as HMG-CoA reductase inhibitors, work by blocking the enzyme that your body needs to produce cholesterol.
Furanocoumarins are organic chemical compounds present in many different plants, including grapefruit.
Grapefruit is one of the healthiest citrus fruits you can eat. Richard N. Fogoros, MD, is a retired professor of medicine and board-certified internal medicine physician and cardiologist. Statin Drugs May Not Be Beneficial for Some Older Adults, What to Know Before Starting a Bile Acid Resin to Lower LDL, What You Should Know About Statin Drug Interactions, How Zocor (Simvastatin) Works to Lower Your Cholesterol, Side Effects of Statin Drugs That Can Affect Your Muscles, Side Effects When Patients Switch to Generic High Blood Pressure Drugs, Chemistry and health effects of furanocoumarins in grapefruit, Basic review of the cytochrome p450 system. What can we help you find? 2013;4(4):263-8. doi:10.6004/jadpro.2013.4.4.7, Lee JW, Morris JK, Wald NJ. One misconception is that you shouldn’t mix grapefruit with any statin drug. But to be on the safe side, check with your doctor, and avoid taking your pills with grapefruit juice. This is known as a drug interaction. This study adds to the growing body of…, A new report on childhood cholesterol levels delivers some promising news, but it's not time to cheer. If you’re prescribed a statin, it’s important to understand which ones can interact negatively with grapefruit and grapefruit juice. This is because the interaction happens in your digestive tract. To be safe, check with your doctor if you take one of the three statins mentioned above. For example, numerous citrus-flavored soft drinks contain grapefruit juice or grapefruit extract. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Just one grapefruit or one glass of grapefruit juice could be enough to cause an interaction in some people. Grapefruit juice can cause problems with these enzymes and transporters, causing too much or too little drug in the body.
The fruit doesn’t affect all statins. According to the U.S. Food and Drug Administration (FDA), grapefruit can affect the rate that your liver processes drugs.
While that may sound oddly specific, there is a good reason why you want to steer clear of this particular fruit. As a result, more of the drug is absorbed, making it more powerful than it's meant to be — even toxic in some cases. The effect remains the same whether you cook the grapefruit or drink frozen or homogenized juice.
What are the risks of mixing grapefruit and certain statins? Some men with an enlarged prostate gland (benign prostatic hyperplasia, or BPH for short) eventually start to experience urinary incontinence, the involuntary discharge of urine. What Is Vitamin F? Grapefruit Juice and Statins. The exact amount of grapefruit it takes to have a negative reaction when taking lovastatin, atorvastatin, or simvastatin is unknown.
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