While early studies confirmed the corrosive and irritant properties of benzalkonium chloride, investigations into the adverse effects of, and disease states linked to, benzalkonium chloride have only surfaced during the past 30 years.
The trimethyl amine group in dimethylbenzylamine can be cleaved to form a benzyl that can be further oxidized to benzoic acid. The substance is an alkyl halide and is a … [citation needed], Benzalkonium chloride degradation follows consecutive debenzylation, dealkylation, and demethylation steps producing benzyl chloride, alkyl dimethyl amine, dimethyl amine, long chain alkane, and ammonia. Type of substance Composition: mono-constituent substance Origin: organic Total tonnage band Total range: Intermediate Use Only REACH Registered as: INTERMEDIATE Submitted: Individual Submission Publication dates First published: 28 … [19], Benzalkonium chloride is irritant to middle ear tissues at typically used concentrations. Since stearalkonium chloride is a type of BAC, the biodegradation process should happen in the same manner.
Molecular Formula C 7 H 5 ClO; Average mass 140.567 Da; Monoisotopic mass 140.002899 Da; ChemSpider ID 7134 [23], Occupational exposure to benzalkonium chloride has been linked to the development of asthma. [2] ADBACs are a mixture of alkylbenzyldimethylammonium chlorides, in which the alkyl group has various even-numbered alkyl chain lengths. M Akers, "Consideration in selecting antimicrobial preservative agents for parenteral product development", Pharmaceutical Technology, May, p. 36 (1984). [24] In 2011, a large clinical trial designed to evaluate the efficacy of hand sanitizers based on different active ingredients in preventing virus transmission amongst schoolchildren was re-designed to exclude sanitizers based on benzalkonium chloride due to safety concerns. Benzalkonium chloride is a mainstay of phase-transfer catalysis, an important technology in the synthesis of organic compounds, including drugs. 4-Phenylbenzoyl chloride.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The 50% solution is purely aqueous, while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) MEDIUM. This results in benzyl dimethyl amine as the first intermediate and dodecanal as the major product.[39]. Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, benzoyl chloride / benzoyl chloride / 98-88-4 / 202-710-8, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution, INEOS ChloroToluenes Belgium nv, H. Hartlaan 21, 3980, Tessenderlo, Belgium. IUPAC Name: benzoyl chloride. Enzymes, which finely control a wide range of respiratory and metabolic cellular activities, are particularly susceptible to deactivation. In a 1998 study using the FDA protocol, a non-alcohol sanitizer with benzalkonium chloride as the active ingredient met the FDA performance standards, while Purell, a popular alcohol-based sanitizer, did not. [21][22] In the United States, nasal steroid preparations that are free of benzalkonium chloride include budesonide, triamcinolone acetonide, dexamethasone, and Beconase and Vancenase aerosol inhalers.
Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. IUPAC Name: Benzoyl chloride CAS Number: 98-88-4. Reference substance name: Benzoyl chloride EC Number: 202-710-8 EC Name: Benzoyl chloride CAS Number: 98-88-4 Molecular formula: C7H5ClO IUPAC Name: benzoyl chloride Benzyl chloride Names Preferred IUPAC name (Chloromethyl)benzene. 14002-51-8. Exit. Please upgrade your Internet Explorer to a newer version. Gram-positive bacteria are generally more susceptible than gram-negative bacteria. This information has not been reviewed or verified by the Agency or any other authority. [citation needed] The use of appropriate excipients can also greatly enhance the spectrum, performance and detergency, and prevent deactivation under use conditions. [37] Activity is not greatly affected by pH, but increases substantially at higher temperatures and prolonged exposure times. Reference substance name: Benzoyl chloride EC Number: 202-710-8 EC Name: Benzoyl chloride CAS Number: 98-88-4 Molecular formula: C7H5ClO IUPAC Name: benzoyl chloride. Benzalkonium chloride is readily soluble in ethanol and acetone. [41], Except where otherwise noted, data are given for materials in their. This information has not been reviewed or verified by the Agency or any other authority. Stronger concentrations can be caustic[11] and cause irreversible damage to the corneal endothelium.
[citation needed] However, prolonged or repeated skin contact may cause dermatitis.
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